Sylodipine 5mg

4.46

100 in stock

Calcium Channel Blocker, Mild to Moderate Hypertension

Formulation:
Each Tablet contains:
Amlodipine (as Besilate)……..…………………………..………………………5 mg

PHARMACOKINETICS:
Amlodipine is well absorbed following oral administration with peak blood concentrations occurring after 6 to 12 hours.
The bioavailability is about 60% to 65%. Amlodipine is reported to be about 97.5% bound to plasma proteins. It has a
prolonged terminal elimination half-life of 35 to 50 hours and steady-state plasma concentrations are not achieved until
after 7 to 8 days of administration. Amlodipine is extensively metabolized in the liver; metabolites are mostly excreted in
the urine together with less than 10% of a dose as unchanged drug.


INDICATIONS:
Used in management of hypertension, stable angina and Prinzmetal’s angina.


PRECAUTIONS:
Amlodipine should be used with caution in patients with hypotension, poor cardiac reserve, and heart failure. The dose
may be reduced in patients with hepatic impairment. Amlodipine during pregnancy should be given only if the potential
benefit justifies the potential risk to the fetus. Use of drug during lactation is not advisable.


CONTRAINDICATION:
Amlodipine should not be given to patients hypersensitive to it.


DOSAGE AND ADMINISTRATION:
Adults: Initial dose of 5 mg once daily, increased, if necessary, to 10 mg once daily. Or as prescribed by a physician.


ADVERSE EFFECTS:
Dizziness, flushing, headache, hypotension, peripheral oedema, tachycardia and palpitations. Nausea and other
gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain, and mental depression have also
occurred. A paradoxical increase in ischaemic chest pain may occur at the start of treatment and in few patients,
excessive fall in blood pressure has led to cerebral or myocardial ischaemia or transient blindness.


DRUG INTERACTIONS:
Amlodipine has been safely administered with thiazide, diuretics, beta blockers, angiotensin converting enzyme inhibitor,
long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drug, antibiotics and oral
hypoglycemic drugs.


CAUTION:
Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.


STORAGE CONDITION:
Store at temperatures not exceeding 30°C. Protect from light.

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